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Clinical trials have shown semaglutide can help patients lose 10 to 15 percent of their body weight when combined with healthy lifestyle changes

Route: IM or IV injection (once or twice per week)

For most patients, tirzepatide is the right choice now, with retatrutide as a potential option in 2028 for those who need more or achieved inadequate results

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Injecting semaglutide directly from cold storage is technically safe but uncomfortable